Increased Bone Mass in Mice after Single Injection of Anti-receptor Activator of Nuclear Factor-κB Ligand-neutralizing Antibody
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منابع مشابه
Increased Bone Mass in Mice after Single Injection of Anti-receptor Activator of Nuclear Factor-κB Ligand-neutralizing Antibody
Receptor activator of nuclear factor-κB ligand (RANKL) is a pivotal osteoclast differentiation factor. To investigate the effect of RANKL inhibition in normal mice, we prepared an anti-mouse RANKL-neutralizing monoclonal antibody (Mab, clone OYC1) and established a new mouse model with high bone mass induced by administration of OYC1. A single subcutaneous injection of 5 mg/kg OYC1 in normal mi...
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Yuriko Furuya, Kaoru Mori, Tadashi Ninomiya, Yoshiya Tomimori, Sakae Tanaka, Naoyuki Takahashi, Nobuyuki Udagawa , Kohji Uchida, and Hisataka Yasuda** From the Nagahama Institute for Biochemical Science, Nagahama Branch, Oriental Yeast Co., Limited, 50 Kano-cho Nagahama, Shiga 526-0804, the **Bioindustry Division, Oriental Yeast Co., Limited, 3-610 Azusawa, Itabashi-ku, Tokyo 174-8505, the Inst...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2011
ISSN: 0021-9258
DOI: 10.1074/jbc.m111.246280